Prolongation of QTc and Risk of Stroke
نویسنده
چکیده
Results The risk of incident stroke in study participants with prolonged QTcFram was almost 3 times the risk in those with normal QTcFram (hazard ratio [HR] [95% confidence interval (CI)]: 2.88 [2.12 to 3.92], p 0.0001). After adjustment for demographics (age, race, and sex), traditional stroke risk factors (antihypertensive medication use, systolic blood pressure, current smoking, diabetes, left ventricular hypertrophy, atrial fibrillation, and previous cardiovascular disease), warfarin use, aspirin use, QRS duration and use of QTc-prolonging drugs, the risk of stroke remained significantly high (HR [95% CI]: 1.67 [1.16 to 2.41], p 0.0061) and was consistent across several subgroups of REGARDS study participants. Similar results were obtained when the risk of stroke was estimated per 1-SD increase in QTcFram, (HR [95% CI]: 1.12 [1.03 to 1.21], p 0.0053 in multivariable-adjusted model) and when other QTc correction formulas including those of Hodge, Bazett, and Fridericia were used.
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